Organic cation transporter 2 (OCT2) has been implicated in cisplatin nephrotoxicity in a study with isolated human proximal tubules [24], and hypomagnesemia results in up-regulation of OCT2 and thereby increases the renal accumulation of cisplatin and exacerbates acute kidney injury in an animal model [25]. The gene discussed is SLC22A2; the disease is Hypomagnesemia.