Notably, genes that are part of the inflammosome complex, and cytokines that are the end product of the activation of such complex, were significantly up regulated in cells carrying the VDR haplotype that correlates with an increased risk of obesity and higher BMI scores; associated with such “at risk” VDR haplotype was also an increased plasma concentration of LPS and a reduced expression of VDR. The gene discussed is VDR; the disease is obesity disorder.