In this respect, Valencia et al. [46] assessed the validity of measuring serum miRNAs in a murine model of human lung cancer bone metastasis and compared miRNA serum levels with those of standard biochemical markers of bone turnover such as PINP (procollagen I amino-terminal propeptide), BGP (osteocalcin) and CTX (carboxyterminal telopeptide). Here, BGLAP is linked to lung carcinoma.