Restoring miR-33a expression reduces the stimulatory effect of lung cancer cells on the production of osteoclastogenesis activator RANKL, (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP and IL-8 are decreased [45]. The gene discussed is PTHLH; the disease is lung carcinoma.