There is low expression in the basal state, but Axl and Gas6 are up-regulated in several murine models of renal disease including: Thy1.1 antibody induced glomerulonephritis, [21] nephrotoxic nephritis [12], streptozotocin-induced diabetic nephropathy [11] and a podocyte ablation model of glomerular albuminuria [26]. This evidence concerns the gene GAS6 and kidney disorder.