Through a series of related studies, we identified the pathway, transforming growth factor (TGF)β → MAP2K4 → p38 MAPK → heat shock protein 27 (HSP27) → matrix metalloproteinase type 2 (MMP-2) → human PCa cell invasion, and that it is inhibited by genistein [11]–[16]. The gene discussed is MMP2; the disease is posterior cortical atrophy.