In step 1, positive ApoE4 status (HR = 1.89, 95% CI: 1.18–3.02) and lower CERAD-DR performance (HR = 0.63, 95% CI: 0.56–0.71) were associated with higher risk of developing incident AD, yielding acceptable model fit (Nagelkerkes R2 = 0.262). Here, APOE is linked to Alzheimer disease.