When the RANK rs1805034 TT homozygote genotype was used as the reference group, the TC genotype was not associated with the risk of ESCC (TC vs. TT: adjusted OR  = 1.16, 95% CI  = 1.03–2.24, p = 0.231), but the CC genotype was associated with the risk of ECSS (CC vs. TT: adjusted OR  = 1.62, 95% CI  = 1.08–2.44, p = 0.019). The gene discussed is TNFRSF11A; the disease is esophageal squamous cell carcinoma.