The functional significance of RANK/RANKL/OPG signaling pathway and pilot study in breast cancer have led us to investigate the association between the esophageal cancer and SNPs in the genes of RANK, RANKL and OPG. In a hospital-based case-control study, we performed genotyping analyses of the five miRNA SNPs in 629 ESCC cases and 686 controls in a Chinese population. This evidence concerns the gene TNFSF11 and breast cancer.