Using Power and Sample Size Calculation (PS, version 3.0.43, 2009, http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/PowerSampleSize), considering RANK rs1805034 T>C mutant alleles, the power of our analysis (α = 0.05) was 0.946 in 629 ESCC cases and 686 control subjects with adjusted OR 1.52. The gene discussed is TNFRSF11A; the disease is esophageal squamous cell carcinoma.