ALDH2 and diabetic cardiomyopathy: Our previous study had reported that, in diabetic rats, ethanol (EtOH) at low concentration offered myocardial protection through activation of ALDH2 expression [8], and upregulation of ALDH2 also plays the protective effect in myocardial ischemia and reperfusion injury, diabetes cardiomyopathy, and kidney and brain injury [9–12]; meanwhile, some researchers reported the association between ALDH2 and lung disease.