NES and melanoma: Despite the controversy whether Nestin-expression is restricted to angiogenic endothelial cells or to Nestin(+) stem cells that associate and integrate into newly formed blood vessels, our results still endorse the idea that a Nestin-targeted therapy may be suited to selectively suppress tumor proliferation via inhibition of neovascularization and vessel stabilization in numerous malignancies, including colorectal cancer and melanomas.