NES and neoplasm: Moreover, we used the transgenic Nestin-GFP mice as well as bone-marrow (BM) chimera of C57Bl/6 wild type (wt) and Nest-GFP mice to trace the recruitment Nestin(+) MPSCs during vascular remodeling of tumor blood vessels in xenograft tumors and to analyze the relative importance of tissue-resident Nestin(+) MPSCs vs. circulating (BM-derived) MPSC.