Despite the controversy whether Nestin-expression is restricted to angiogenic endothelial cells or to Nestin(+) stem cells that associate and integrate into newly formed blood vessels, our results still endorse the idea that a Nestin-targeted therapy may be suited to selectively suppress tumor proliferation via inhibition of neovascularization and vessel stabilization in numerous malignancies, including colorectal cancer and melanomas. Here, NES is linked to colorectal cancer.