DKK1 and colonic neoplasm: Dickkopf-1 (Dkk1) is a potent inhibitor of Wnt signaling, and the expression of Dkk1 was reduced in colon cancer, with a concomitant reduction in immunohistochemical features of EMT (such as increased expression of the epithelial marker E-cadherin, decreased expression of the mesenchymal marker vimentin, and cytoplasmic distribution of β-catenin).