CASP3 and colorectal carcinoma: In agreement with this hypothesis, it was demonstrated that NAMI-A induced apoptosis in the ECV304 transformed human endothelial and KP1019 in colorectal carcinoma cell lines via activation of caspase-3 and DNA fragmentation (Bortner et al.1995; Nunez et al.1998; Kapitza et al.2005).