In this comparison, the values of CA 125 and YKL-40 were significantly statistically higher in the group of refractory and resistant cases as compared with cases of ovarian cancer sensitive to chemotherapy based on platinum (CA 125 1058.15 vs 575.77, p = 0.0324, YKL-40 193.53 vs 131.04, p = 0.0339). The gene discussed is CHI3L1; the disease is ovarian carcinoma.