In our study, the area under the curve was assessed for HE4 at 0.949 level for all the patients and 0.941 in the serous carcinomas group and these are the results that show a high potential of the marker HE4 in predicting the optimal cytoreduction which is consistent with all previous studies by other authors [15,31-33]. This evidence concerns the gene WFDC2 and serous adenocarcinoma.