When comparing the mean values of the concentrations of selected tumor markers (CA125, HE4, YKL-40), cathepsin-L and bcl-2 we found that statistically significant differences between a group of women undergoing primary surgical treatment and the patients qualified as eligible for the neoadjuvant chemotherapy were applicable only to the tumor markers (CA125 1206.79 vs 2432.38, p = 0.000191; HE4 78.87 vs 602.45, p = 0.000004; YKL-40 108.13 vs 203.96, p = 0.003991). The gene discussed is WFDC2; the disease is neoplasm.