By targeting IGF-1 and p85α proteins, miR-29 inhibited muscle protein synthesis and myogenesis since IGF-1 and p85α are well established signaling molecules for protein translation and a decrease in these proteins was observed during muscle atrophy including sarcopenia (Owino et al., 2001; Barbour et al., 2005; Park et al., 2009; Smith et al., 2012). Here, IGF1 is linked to sarcopenia.