GJA1 and breast carcinoma: In addition, a recent study demonstrated that increased post-treatment Cx43 levels were significantly associated with response to neoadjuvant chemotherapy in human breast carcinomas (Teleki et al., 2013) and high tumor Cx43 expression by immunohistochemistry was predictive of response to platinum-based chemotherapy in non-small cell lung cancer (Du et al., 2013).