Aiming to characterize Cx43 expression in native human lymphoid tissues and lymphoid malignancies, preliminary experiments from our group using chromogenic immunohistochemistry detected low levels of Cx43 protein in formalin fixed-paraffin embedded samples from 4 non-tumor lymph nodes and absence of signal in a set of 22 malignant B cell lymphomas (13 Diffuse large B cell lymphomas [DLBCL] and 9 classical Hodgkin lymphomas [CHL]) (Figure 3). This evidence concerns the gene GJA1 and diffuse large B-cell lymphoma.