GJA1 and neoplasm: As an integral component of the CD38-Cx43-cADPR axis and NAD+ degradation pathway, it is tempting to speculate that expression of Cx43 in neoplastic cells could serve as a prognostic/predictive biomarker for such compounds and modulation of Cx43 hemichannels may itself represent a novel anti-tumor therapeutic target, especially in CD38 expressing B cell malignancies.