APP and Alzheimer disease: Indications for disturbances in axonal transport with concomitant axonopathy have been described in different APP-based transgenic AD mouse models (Stokin et al., 2005; Salehi et al., 2006; Wirths et al., 2006, 2007; Adalbert et al., 2009; Chen et al., 2011; Jawhar et al., 2012).