RTN4 and stroke disorder: Acute intrathecal anti-Nogo-A antibody infusion over 2 weeks after stroke, with an application starting early after incident (Wiessner et al., 2003; Tsai et al., 2007), or delayed application starting 9 weeks after stroke in adult rats (Tsai et al., 2011) significantly improved forelimb function and was correlated with a significant increase of midline crossing corticospinal fibers originating in the unlesioned sensorimotor cortex.