In conclusion, the present study revealed that the increased expression of OCT4 is correlated with the degree of differentiation of pancreatic cancer, while knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of AKT pathway-mediated PCNA and MMP-2 expression, suggesting that OCT4 may serve as a potential therapeutic target for the treatment of pancreatic cancer. This evidence concerns the gene MMP2 and familial pancreatic carcinoma.