In addition, the endogenous expression of PCNA, indicated by western blot analysis, was significantly decreased in the Lv-shOCT4 group compared with the NC and CON groups (P<0.01; Fig. 4B and C), indicating that knockdown of OCT4 may inhibit the invasive potential of pancreatic cancer cells through downregulation of PCNA expression. This evidence concerns the gene PCNA and familial pancreatic carcinoma.