Consistent with the aforementioned studies, our results showed that ischemic cerebral infarcts induced by 40 min MCAO and 48 h reperfusion resulted in significantly larger infarct volumes, neurological deficits and motor deficits in ApoE KO mice fed HFD for 10 weeks when compared to ApoE KO mice fed a regular diet. Here, APOE is linked to brain infarction.