TNF and atherosclerosis: The focus of the present study was CYP2C8 and its capacity to elucidate how the arachidonic acid metabolites, EETs, attenuate TNF-α induced inflammation through ROS in vascular endothelial cells and macrophages and improve endothelial function and provide new insight into how CYP2C8-derived EETs ameliorate vascular inflammatory diseases such as atherosclerosis.