The lack of an affect on caspase-9 expression supports the notion that FC101 does not induce apoptotic cell death in glioblastomas via an intrinsic mechanism, as suggested in in another study of ours [Mahdavian et al (unpublished data)], which showed that FC101 had no effect on intrinsic apoptotic pathway proteins (BAD, BAK and BAX) in breast cancer cells. The gene discussed is BAX; the disease is breast carcinoma.