The associations between IL-23p19 nuclear staining and favorable prognostic features were exclusively maintained in the CD8+ T-cell high group (Table 3), namely with smaller tumour diameter (p=0.0001), earlier pT stage (p=0.022), lymph node negativity (p=0.0274), earlier TNM stage (p=0.0017) and absence of lymphatic invasion (p=0.033). This evidence concerns the gene IL23A and neoplasm.