We also confirmed the upregulation of DR5 in PC-3 cells by combination of Tanshinone I and TRAIL by promoter assay and FACS analysis for cell surface DR5 expression, demonstrating that Tanshinone I can sensitize prostate cancer cells to TRAIL induced apoptosis via upregulation of DR5 and suppression of survival genes. This evidence concerns the gene TNFRSF10B and Familial prostate cancer.