The Orai1 inhibitor 2-APB (50 μM) decreased the peak Ca2+ increase from 0.19 ± 0.02 arbitrary units (n = 6) to 0.07 ± 0.01 arbitrary units (n = 5) in A2780 ovary carcinoma cells and from 0.49 ± 0.03 arbitrary units (n = 6) to 0.04 ± 0.01 arbitrary units (n = 5) A2780cis ovary carcinoma cells (Fig. 4). The gene discussed is ORAI1; the disease is ovarian carcinoma.