In order to test whether Akt sensitive regulation of Orai1 influenced the sensitivity of the ovary carcinoma cells to therapy, the effect of cisplatin on apoptosis of therapy sensitive A2780 and therapy resistant A2780cis cells was tested in the absence and presence of either Akt inhibitor SH-6 or Orai1 inhibitor 2-aminoethoxydiphenyl borate (2-APB). Here, AKT1 is linked to ovarian carcinoma.