Specifically in HCC, although there is increasing work in the study of deregulated miRNAs in various liver CSC subsets as compared with non-CSC differentiated counterparts, for example miR-181 in EpCAM+ liver CSCs [13], miR-150 up-regulation in CD133+ liver CSCs [14] and our previous work on miR-130b and TP53INP1 interaction in CD133+ liver CSCs [3], the role of miRNAs in the direct regulation of CD133 in HCC has not been explored. Here, EPCAM is linked to hepatocellular carcinoma.