Further, shortly prior to the submission of this article, a study by Shen et al. found miR-142-3p to function as a tumor suppressor in colon cancer cells by targeting CD133, ABCG2 and LGR5 [19], though no rescue functional experiments were performed to delineate which of the three cellular targets was most crucial in mediating the effects of miR-142-3p in colon cancer cells. The gene discussed is LGR5; the disease is malignant colon neoplasm.