In the West African setting, the 202A allele frequency across ethnic groups is frequently substantially lower than deficiency rates, and inclusion of alternative G6PD alleles (Santamaria 542 T/376G - ~2% residual enzymatic activity, Betica-Selma 968C/376G - ~11% activity)[11,12] has captured an association with severe malaria in The Gambia[8]. The gene discussed is G6PD; the disease is malaria.