Interestingly, we observed that in leukemia patients, higher levels of DNMT are accompanied by NCL overexpression, while lower expression of DNMT is seen in the patients carrying lower NCL transcription, indicative of a positive correlation between NCL and DNMT transcripts (Fig. 3A-B), which was independently confirmed by other datasets, GSE16432 (myeloid leukemia, GPL10105–10108, n = 86; GPL8651–8653, n = 88) (Supplementary Fig. S3). The gene discussed is DNMT1; the disease is leukemia.