Recent studies have also demonstrated that p53, the most frequently mutated human cancer gene, and its family member p73 are involved in the regulation of glucose and glutamine metabolism (Amelio et al., 2013; Berkers et al., 2013; Candi et al., 2014; Du et al., 2013; Fets and Anastasiou, 2013; Jiang et al., 2013c; Liang et al., 2013; Lunt and Vander Heiden, 2011; Shen et al., 2012). The gene discussed is TP53; the disease is cancer.