The inhibition of CIP2A has been shown to determine the effect of bortezomib on apoptosis and PP2A-dependent AKT inactivation in hepatocellular carcinoma indicating that CIP2A may be a biomarker for predicting clinical response of bortezomib in hepatocellular carcinoma treatment [91]. The gene discussed is CIP2A; the disease is hepatocellular carcinoma.