In their study a PP2A activator FTY720 impaired proliferation and clonogenic potential of cells, induced caspase-dependent apoptosis, affected AKT and ERK1/2 activation status and showed an additive effect with drugs used in standard chemotherapy (5-fluorouracil, SN-38 and oxaliplatin) in colorectal cancer patients. This evidence concerns the gene PTPA and colorectal cancer.