It is intriguing how the interactions of CIP2A (“oncogenic nexus”) with all different cellular components/signaling molecules function in complex co-ordinated ways to (1) enhance the activity of onco-proteins, (2) suppress the function of tumor suppressors, (3) stabilize pro-oncogenic transcription factors, (4) facilitate the function of other transcription factors and / or (5) control cell growth, protein synthesis and autophagy through growth factors, nutrients, energy sensors and mTORC1 which eventually signals towards oncogenic transformation of a cell. Here, CIP2A is linked to neoplasm.