These effects not only confirm the pivotal role of CIP2A in the “oncogenic nexus”, but also helps to understand the mechanism of action of CIP2A in (1) the cellular transformation (oncogenic) and the progression of cancer cells (e.g. EMT), (2) mediating different drug responses (as drug target), (3) mediating drug-induced resistance and (4) determining the prognosis of a disease. Here, CIP2A is linked to cancer.