As an integral protein, CIP2A functions via protein binding through interactions with many proteins including PP2A, (a tumor suppressor), MYC, (a pleiotropic transcription factor; MYC proto-oncogene protein, a class E basic helix-loop-helix protein 39; Transcription factor p64), polo like kinase (PLK1), and NIMA (Never In Mitosis Gene A)-related kinase 2 (NEK2) protein. Here, CIP2A is linked to neoplasm.