Scl ChIP-Seq in T-ALL cell lines and primagrafts showed consistent binding patterns with E-box, Gata, Runx and Ets motifs identified within 200 bp of the Scl binding, and frequent regions of overlap between Scl and the TFs E2A, Heb, Lmo1, Lmo2, Gata3 and Runx1. The gene discussed is GATA3; the disease is acute lymphoblastic leukemia.