Interdependence between Scl, Runx1 and Gata3 was suggested by the presence of reciprocal binding at regulatory elements on loci by members of the complex in T-ALL cells, and reciprocal shRNA knockdown of each of the triad members caused down-regulation of the others, as well as inhibiting cell growth and promoting apoptosis. Here, TAL1 is linked to acute lymphoblastic leukemia.