Scl ChIP-Seq in T-ALL cell lines and primagrafts showed consistent binding patterns with E-box, Gata, Runx and Ets motifs identified within 200 bp of the Scl binding, and frequent regions of overlap between Scl and the TFs E2A, Heb, Lmo1, Lmo2, Gata3 and Runx1. This evidence concerns the gene TAL1 and acute lymphoblastic leukemia.