The role of Runx1–ETO (commonly referred to as AML1–ETO) in t(8;21) AML is well recognised [77], where it is generally thought to act as transcriptional repressor through recruitment of NCOR and HDAC proteins [78], [79], [80] and reduction of histone acetylation [81]. Here, RUNX1T1 is linked to acute myeloid leukemia.