HMGA2 and acute lymphoblastic leukemia: Several studies report direct involvement of HMGA2 locus chromosomal translocations in the pathogenesis of several types of leukemia such as B-cell chronic lymphocytic leukemia and acute myeloid leukemia,10 and one study has linked the rearrangement of the HMGA2 locus with the development of T-ALL.11 It has also been demonstrated that human HMGA2 expressed in mice causes the onset of pituitary adenomas by enhancing E2F1 activity.12 Overexpression of the truncated form of human HMGA2, lacking the C-terminal tail, leads to the development of natural killer (NK) T-cell lymphoma in mice.9