HMGA2 and acute lymphoblastic leukemia: Abnormal cytokine production, immune incompetence, an extensive proliferation rate and hypogammaglobulinemia are important features of T-ALL in human patients.2, 3, 17 We showed that Eμ-HMGA2 transgenic mice also have hypogammaglobulinemia, a threefold decrease in the immune response against the foreign antigen KHL, and elevated levels of the cytokines' tumor necrosis factor alpha and IL-6.