KEAP1 and neoplasm: The other Keap1 binding proteins, such as the Wilms tumor gene on the X chromosome (WTX) [42], PALB2/FANCN [43], and dipeptidyl peptidase 3 (DPP3) [44] also contain the ETGE motif in common and can promote the Nrf2 protein stability by competitively binding to Keap1.