In the present study, we observed that the heterozygote CT for rs957970 increased the risk of hyperlipidemia by 1.43 times in comparison with the major TT homozygote, which suggested that C allele carriers for rs957970 might have lower expression of STAT3, in view of the major observations of the down-regulatory effects of STAT3 on lipogenic genes expression. Here, STAT3 is linked to hyperlipidemia.