Previous studies have identified many different genes that are involved in metastasis of NPC, accelerating or suppressing metastasis by a mechanism of cooperative or inhibitive interactions between genes, such as LMP1 [18], NGX6 [19]–[20], Fibulin-5 [21], IntergrinαV[22], MIF and DJ-1[23] and so on. The gene discussed is MIF; the disease is nasopharyngeal carcinoma.