We originally reported on the pro-apoptotic function of ZFP36L1 in Ramos Burkitt B lymphoma cells [10] and more recently in Rituximab-induced apoptosis of B-chronic lymphocytic leukaemia cells (BCLL) [11] from which the human ZFP36L1 gene was originally isolated as an early response gene cDNA [12]. The gene discussed is ZFP36L1; the disease is B-cell chronic lymphocytic leukemia.