Due to the known associations of fibulin-1 with cardiac overload, as well as restrictive cardiomyopathy and decreased left ventricular (LV) systolic function in patients with symptomatic severe aortic stenosis [13], we hypothesize that fibulin-1 could be a potential biomarker of either early cardiac or valvular fibrosis. Here, FBLN1 is linked to aortic stenosis.