FBLN1 and aortic valve insufficiency: Fibulin-1 correlated inversely with AVAI at baseline (p = 0.001), 1 year follow-up (borderline p = 0.062) and 4 year follow-up (p<0.001), but no significant trend was observed with LV mass index, aortic regurgitation, LV ejection fraction and mid-wall shortening (only baseline data available) at any time point.