In the moderate AS group (Table S3 in File S1) fibulin-1 associated strongly with NT-proBNP at baseline (p = 0.001), 1 year (p = 0.003) and 4 years (p = 0.004) of treatment and with suPAR at both 1 year (p = 0.003) and 4 years (p<0.001) follow-up. This evidence concerns the gene NPPB and aortic stenosis.