AGT and ventricular tachycardia: As shown in Figure 5, mice treated with Ang II alone showed significant a higher susceptibility of VT/VF that is characterized as remarkably lower pacing threshold leading to ventricular tachycardia or fibrillation (6.5±2.9 mA) compared with the mice co-treated with Ang II and PAP (21.6±3.8 mA, p<0.05), which suggests PAP prevents ventricular arrhythmogenesis in Ang II induced hypertrophic mice.