Chang et al reported that rCBF abnormalities correlated significantly with clinical disease severity as measured by CD4 count, plasma viral load, Karnofsky score, and HIV dementia scale, but they evaluated patients with HIV-cognitive motor complex, who presented with the mean AIDS dementia complex (ADC) stage ranging from 0.5 to 2 (moderate dementia) [34]. The gene discussed is CD4; the disease is AIDS dementia complex.