CTLA4 and neoplasm: Moreover, these results confirm that combination therapy with focal RT and CTLA-4 blockade prolong overall survival resulting in long-term tumor free survival in 25% of treated mice from the earlier time points group (day 8–10–12), 22% long-term survival in treated mice from the middle time points group (day 10–12–14), and 12.5% long-term survival in treated mice from the later time points group (day 12–14–16).