In the CT26 subcutaneous tumor model (Fig. 4A, left bottom panel), the number of viable CT26 target cells was decreased by SART3/CD40L+GM-CSF gene-loaded polyplex micelles, but not mock control, GM-CSF- or SART3+GM-CSF gene-loaded polyplex micelles. The gene discussed is DDX53; the disease is neoplasm.