The objective of this study was to establish the capacity of liver fibrosis, its associated genetic polymorphisms (polymorphism of TNF-α and IL-10 genes) and other well-known parameters influencing the response to Peg-IFN and RBV, to accurately predict SVR in HIV/HCV coinfected patients, grouped as a function of the HCV genotype. Here, TNF is linked to Hepatic fibrosis.