In the present study, we demonstrated that BDSW inhibits hyperglycemia, improves glucose intolerance and pancreatic function, and increases glucose uptake through the phosphorylation of signal molecules related to glucose uptake such as IRS-1, LKB1, AMPK, and mTOR in the skeletal muscle of STZ-induced diabetic mice. Here, IRS1 is linked to Hyperglycemia.