In the present study, we demonstrated that BDSW inhibits hyperglycemia, improves glucose intolerance and pancreatic function, and increases glucose uptake through the phosphorylation of signal molecules related to glucose uptake such as IRS-1, LKB1, AMPK, and mTOR in the skeletal muscle of STZ-induced diabetic mice. The gene discussed is STK11; the disease is Glucose intolerance.