Patients with CHF caused by ICM and DCM displayed a pronounced loss of miR-126 and miR-130a in angiogenic early outgrowth cells (EOCs) and in circulating CD34+ cells as well as in their respective targets, the SPRED-1 and the homeobox A5 (HOXA5) [142]. The gene discussed is HOXA5; the disease is familial dilated cardiomyopathy.