This study also suggested that dysregulation of miR-146a/b expression may contribute to prolonging the activation of Toll-like receptor 4 (TLR4) which, in turn, may induce miR-146a/b expression as a negative regulator and, so, induce progression of coronary atherosclerosis in patients with CAD [88]. This evidence concerns the gene TLR4 and coronary atherosclerosis.