Elevated serum levels of miR-423-5p, miR-320a, miR-22, and miR-92b, identified in systolic heart failure patients, were correlated with important clinical prognostic parameters, like elevated serum brain natriuretic peptide (BNP) concentrations, a wide QRS, and dilatation of the left ventricle and left atrium [138]. The gene discussed is NPPB; the disease is systolic heart failure.