NELFA and cardiac hypertrophy: In fact, in mice overexpressing miR-133a there was a reduction of hypertrophy by suppression of its cardiomyocyte targets [152] that included RhoA, a GDP-GTP exchange protein regulating cardiac hypertrophy, cell division control protein 42 (Cdc42), a signal transduction kinase implicated in hypertrophy, and the negative elongation factor A/Wolf-Hirschhorn syndrome (NELF-A/WHSC2), a nuclear factor involved in cardiogenesis [151].