Nineteen patients (48%) had at least two aPL determinations, 12 (63%) of them being positive (5 with IgG aCL plus LA, 4 with IgG aCL only, 2 with IgM aCL plus LA, and one with LA plus IgM plus IgGaCL), and only two of them had antiphospholipid syndrome. This evidence concerns the gene CD40LG and antiphospholipid syndrome.