Simultaneously, AKI induces NGAL mRNA upregulation in the liver, in the lung, and in various distant organs, originating a rapid release of NGAL into the circulation, called “NGAL systemic pool.” Finally, uNGAL may originate both from circulating NGAL and from the distal nephron, and this hypothesis has been recently reported as “two-compartment model of NGAL trafficking during AKI” [102]. Here, LCN2 is linked to acute kidney injury.