Angiogenesis in MM is the result of physical factors such as hypoxia and chemical substances such as hypoxia-inducing factors (HIFs), VEGF, fibroblast growth factor (FGF), hepatocyte growth factor (HGF), angiopoietin, platelet derived growth factors (PDGF), and endothelial growth factor (EGF), whose concentration is much higher in BM than in peripheral blood of MM patients [44]. Here, VEGFA is linked to Miyoshi myopathy.