Our group has recently described that the majority of MM cells from BM specimens at different stages of disease almost exclusively express the cytoplasmic (inactive) form of NF-κB while, in mesenchymal cells from MM-patients, NF-κB is present in the nuclear active form, further underlining the relevance of BM mesenchymal cells [37]. The gene discussed is NFKB1; the disease is Miyoshi myopathy.