After adhesion, increased bone resorbing activity by osteoclasts and MM survival is mediated by a variety of osteoclast-activating factors, such as macrophage inflammatory protein-1α (MIP-1α), receptor of NF-κB ligand (RANKL), VEGF, TNF-α, IL-1β, HGF, and IL-6, produced by both tumor as well as stromal cells. This evidence concerns the gene IL6 and Miyoshi myopathy.