Moreover, in leukemia, the protein kinase C (PKC) modulator byrostatin induces myeloid leukemia cell lines to produce TNF, resulting in autocrine engagement of TNF-receptors and apoptosis induction through a mechanism that is suppressible by TNFR-Fc fusion protein and caspase-8 dominant-negative [238]. The gene discussed is CASP8; the disease is leukemia.