Other strategies for countering Bcl-2 and Bcl-xL in cancer include over-expression of opposing proapoptotic family members such as Bax with p53 adenovirus (in Phase III trials) or with Mda7 (IL-24) adenovirus gene therapy (completed Phase I trials), as well as Bax adenovirus gene therapy for regional cancer control. Here, IL24 is linked to cancer.