XRCC1 and central nervous system cancer: A meta-analysis of 11 case-control studies with 3,810 cases and 6,079 control subjects reported that the XRCC1 Arg399Gln polymorphism was moderately associated with an increased risk of gliomas in Asian individuals, while the XRCC1 Arg194Trp and XRCC1 Arg280His polymorphisms demonstrated no significant affects (29).