Since the GG genotype indicated a tendency for a higher prostate cancer risk in terms of the rs2240308 SNP (G/A) of the Axin2 gene, the present study next analyzed the association between the GG or non-GG genotypes and the clinical characteristics of cancer aggressiveness, Gleason score, PSA level, age at diagnosis, smoking and drinking status and hypertension. This evidence concerns the gene KLK3 and Familial prostate cancer.