Since the GG genotype indicated a tendency for a higher prostate cancer risk in terms of the rs2240308 SNP (G/A) of the Axin2 gene, the present study next analyzed the association between the GG or non-GG genotypes and the clinical characteristics of cancer aggressiveness, Gleason score, PSA level, age at diagnosis, smoking and drinking status and hypertension. The gene discussed is PROS1; the disease is Familial prostate cancer.