Among these Axin2 SNPs, a significant association between rs2240308 [guanine (G)/adenine (A); also described as 148 cytosine (C)/thymine (T), or CCT/TCT (Proline (Pro)/Serine (Ser)), or Pro50Ser] and the risk of lung cancer has been reported previously (14,15). The gene discussed is AXIN2; the disease is lung carcinoma.