Therefore, in the present study it was hypothesized that when there is a cross-link between the 5-FU-induced PKCδ activation and the caspase-dependent apoptosis that is induced by 5-FU in CRC cells, it may be via the c-Abl-PKCδ-p38 MAPK signaling pathway. Here, PRKCD is linked to colorectal carcinoma.