In the current study, the full-length PKCɛ was found to be particularly small in the two cell lines prior to and following treatment with 5-FU, and was not found to undergo cleavage or phosphorylation following treatment with 5-FU, which indicated that PKCɛ is not involved in the resistance of CRC to 5-FU-induced apoptosis. This evidence concerns the gene PRRT2 and colorectal carcinoma.