PRKCD and colorectal carcinoma: The kinetics of PKCδ activation following treatment with 5-FU in CRC cells was studied by western blot analysis using specific antibodies against PKCδ, as well as p-PKCδ (F-7) that targets the phosphorylated Thr 505 of PKCδ (the activation loop motif), and p-PKC (Ser 645), which targets the phosphorylated Ser 645 of PKCδ (the turn motif).