It might be possible that these negative results were explained by type 2 diabetic patients with advanced atherosclerosis and patients with diabetes, in contrast with critically ill patients without previously diagnosed diabetes, were not affected by GV because of the ability of cells to adapt to the harmful effects of changing ambient glucose [7] and insulin per se neutralize the deleterious effects of GV on oxidative stress in patients treated with it [25]. The gene discussed is INS; the disease is diabetes mellitus.